I'm not sure whether this should go under "Comedy" or "Whatever Else...and Music", so if people think it doesn't belong here, please feel free to move it to the other place.
From Cartoon Network's press release, April 2010: Produced by Warner Bros. Animation and using the iconic MAD magazine, published by DC Comics, as inspiration, MAD is an animated sketch-comedy series utilizing a chaotic mix of animation styles and twisted humor to pull back the curtain and expose the truth behind movies, TV shows, games, pop culture and, of course, curtains! Classic MAD magazine characters and features such as Alfred E. Neuman and Spy vs. Spy pop up, and no subject matter or individual will be safe from MAD's barrage of parodies and sketches. In the end, viewers won't get even, they'll just get MAD! Sam Register (Teen Titans, Ben 10, Batman: The Brave and the Bold) is the executive producer. Kevin Shinick (Robot Chicken) and Mark Marek (KaBlam! The Andy Milonakis Show) are the producers.
The show premieres Monday, September 6 on Cartoon Network.